Induced pluripotent stem (iPS) cells are derived by epigenetic reprogramming, but their DNA
methylation patterns have not yet been analyzed on a genome-wide scale. Here, we find …

Epigenetic modifications must underlie lineage-specific differentiation as terminally
differentiated cells express tissue-specific genes, but their DNA sequence is unchanged …

Background During the past 5 years, high-throughput technologies have been successfully
used by epidemiology studies, but almost all have focused on sequence variation through …

The epigenome consists of non–sequence-based modifications, such as DNA methylation,
that are heritable during cell division and that may affect normal phenotypes and …

Cytomegalovirus (CMV), a prevalent pathogen, causes severe disease in
immunocompromised humans. However, present understanding is limited regarding the …

Objective: To validate the 2010 American Joint Committee on Cancer (AJCC) and 2006
European Neuroendocrine Tumor Society (ENETS) tumor staging systems for pancreatic …

While genome-wide association studies are ongoing to identify sequence variation
influencing susceptibility to major depressive disorder (MDD), epigenetic marks, such as …

Introduction Most anxiolytics and sedative regimens in the intensive care unit (ICU) impair
intellectual function, reducing patient autonomy, and often add to patient morbidity. Using an …

With the growth of the patient safety movement and development of methods to measure
workforce health and success have come multiple modes of assessing healthcare worker …

Background Microarray technology has become a widely used tool in the biological
sciences. Over the past decade, the number of users has grown exponentially, and with the …