Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections
Increasing multidrug resistance in Gram-negative bacteria, in particular Pseudomonas
aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae, presents a critical …
aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae, presents a critical …
Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review
Polymyxins have re-emerged in clinical practice owing to the dry antibiotic development
pipeline and worldwide increasing prevalence of nosocomial infections caused by multidrug …
pipeline and worldwide increasing prevalence of nosocomial infections caused by multidrug …
Evaluation of colistin as an agent against multi-resistant Gram-negative bacteria
Infections caused by multi-resistant Gram-negative bacteria, particularly Pseudomonas
aeruginosa, are increasing worldwide. In patients with cystic fibrosis (CF), resistance in P …
aeruginosa, are increasing worldwide. In patients with cystic fibrosis (CF), resistance in P …
Heteroresistance to Colistin in Multidrug-Resistant Acinetobacter baumannii
Multidrug-resistant Acinetobacter baumannii has emerged as a significant clinical problem
worldwide and colistin is being used increasingly as “salvage” therapy. MICs of colistin …
worldwide and colistin is being used increasingly as “salvage” therapy. MICs of colistin …
International consensus guidelines for the optimal use of the polymyxins: endorsed by the American college of clinical pharmacy (ACCP), European society of clinical …
BT Tsuji, JM Pogue, AP Zavascki… - … : The Journal of …, 2019 - Wiley Online Library
The polymyxin antibiotics colistin (polymyxin E) and polymyxin B became available in the
1950s and thus did not undergo contemporary drug development procedures. Their clinical …
1950s and thus did not undergo contemporary drug development procedures. Their clinical …
Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production
Infections caused by multidrug-resistant (MDR) Gram-negative bacteria represent a major
global health problem. Polymyxin antibiotics such as colistin have resurfaced as effective …
global health problem. Polymyxin antibiotics such as colistin have resurfaced as effective …
Structure− activity relationships of polymyxin antibiotics
The world is facing an enormous and growing threat from the emergence of bacteria that are
resistant to almost all available antibiotics. 1 Multidrug resistance is a significant public …
resistant to almost all available antibiotics. 1 Multidrug resistance is a significant public …
Population pharmacokinetics of colistin methanesulfonate and formed colistin in critically ill patients from a multicenter study provide dosing suggestions for various …
SM Garonzik, J Li, V Thamlikitkul… - Antimicrobial agents …, 2011 - Am Soc Microbiol
With increasing clinical emergence of multidrug-resistant Gram-negative pathogens and the
paucity of new agents to combat these infections, colistin (administered as its inactive …
paucity of new agents to combat these infections, colistin (administered as its inactive …
Colistin in the 21st century
Because few, if any, new antibiotics with activity against multidrug-resistant Gram-negative
bacteria will be available within the next several years, it is essential that colistin is used in …
bacteria will be available within the next several years, it is essential that colistin is used in …
Pharmacology of polymyxins: new insights into an 'old'class of antibiotics
Increasing antibiotic resistance in Gram-negative bacteria, particularly in Pseudomonas
aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae, presents a global …
aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae, presents a global …