Drug and vaccine development for the treatment and prevention of urinary tract infections
VP O'brien, TJ Hannan, HV Nielsen… - Urinary Tract Infections …, 2017 - Wiley Online Library
Urinary tract infections (UTI) are one of the most common bacterial infections, with roughly
eleven‐million cases reported in the US each year that cost an estimated $5 billion annually …
eleven‐million cases reported in the US each year that cost an estimated $5 billion annually …
Urinary tract infection as a preventable cause of pregnancy complications: opportunities, challenges, and a global call to action
NM Gilbert, VP O'brien, S Hultgren… - Global advances in …, 2013 - journals.sagepub.com
The urinary tract is a common site of infection in humans. During pregnancy, urinary tract
infection (UTI) is associated with increased risks of maternal and neonatal morbidity and …
infection (UTI) is associated with increased risks of maternal and neonatal morbidity and …
Are you experienced? Understanding bladder innate immunity in the context of recurrent urinary tract infection
VP O'Brien, TJ Hannan, AJ Schaeffer… - Current opinion in …, 2015 - journals.lww.com
The innate immune response plays a key role in determining susceptibility to rUTI. Future
studies should be directed towards understanding how the innate immune response …
studies should be directed towards understanding how the innate immune response …
The impact of a set of interventions to reduce interruptions and distractions to nurses during medication administration
E Relihan, V O'Brien, S O'Hara… - Quality and Safety in …, 2010 - qualitysafety.bmj.com
Objective To assess the impact of a set of interventions in reducing the
interruption/distraction rate during medication administration. Design and participants Pre …
interruption/distraction rate during medication administration. Design and participants Pre …
[HTML][HTML] Uropathogenic Escherichia coli infection-induced epithelial trained immunity impacts urinary tract disease outcome
SK Russell, JK Harrison, BS Olson, HJ Lee… - Nature …, 2023 - nature.com
Previous urinary tract infections (UTIs) can predispose one to future infections; however, the
underlying mechanisms affecting recurrence are poorly understood. We previously found …
underlying mechanisms affecting recurrence are poorly understood. We previously found …
[HTML][HTML] Transient microbiota exposures activate dormant Escherichia coli infection in the bladder and drive severe outcomes of recurrent disease
NM Gilbert, VP O'Brien, AL Lewis - PLoS pathogens, 2017 - journals.plos.org
Pathogens often inhabit the body asymptomatically, emerging to cause disease in response
to unknown triggers. In the bladder, latent intracellular Escherichia coli reservoirs are …
to unknown triggers. In the bladder, latent intracellular Escherichia coli reservoirs are …
A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease
Recurrent bacterial infections are a significant burden worldwide, and prior history of
infection is often a significant risk factor for developing new infections. For urinary tract …
infection is often a significant risk factor for developing new infections. For urinary tract …
The benefits and challenges of kinship care
V O'Brien - Child Care in Practice, 2012 - Taylor & Francis
The outcomes for children in kinship care are generally seen as positive in terms of identity
formation, stability of placement, behavioural and mental health outcomes, enabling siblings …
formation, stability of placement, behavioural and mental health outcomes, enabling siblings …
Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy
TA Glauser, K Holland, VP O'Brien… - Annals of …, 2017 - Wiley Online Library
Objective To determine whether common polymorphisms in CACNA1G, CACNA1H,
CACNA1I, and ABCB1 are associated with differential short‐term seizure outcome in …
CACNA1I, and ABCB1 are associated with differential short‐term seizure outcome in …
[HTML][HTML] Glycan cross-feeding supports mutualism between Fusobacterium and the vaginal microbiota
K Agarwal, LS Robinson, S Aggarwal, LR Foster… - PLoS …, 2020 - journals.plos.org
Women with bacterial vaginosis (BV), an imbalance of the vaginal microbiome, are more
likely to be colonized by potential pathogens such as Fusobacterium nucleatum, a bacterium …
likely to be colonized by potential pathogens such as Fusobacterium nucleatum, a bacterium …